Hydroxylated Fatty Acids: The Role of the Sphingomyelin Synthase and the Origin of Selectivity
Sphingolipids are a class of lipids acting as key modulators of many physiological and pathophysiological processes.Hydroxylation patterns have a major influence on the biophysical properties of sphingolipids.In this work, we have studied the mechanism of action of hydroxylated lipids in sphingomyelin synthase (SMS).The structures of the two human